PKNOX2-AS1

Across TCGA pan-cancer cohorts, PKNOX2-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PKNOX2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PKNOX2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PKNOX2-AS1 is over-expressed in tumor, although a few such as LUAD and HNSC show the opposite, repressed pattern.

LUAD, HNSC, and LUSC are the cancer types where PKNOX2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PKNOX2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	−0.207	<.001	7	view →
HNSC	All	All	−0.022	.015	6	view →
LUSC	Male	II,III,IV	−0.325	<.001	5	view →
KIRP	Male	II,III,IV	−0.055	.014	5	view →
KICH	All	All	−0.073	.001	4	view →
STAD	All	All	−0.067	.014	4	view →
BRCA	Female	II,III,IV	−0.026	.003	4	view →
THCA	All	All	−0.273	<.001	3	view →
PRAD	All	All	−0.100	.006	2	view →
KIRC	Male	All	−0.029	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PKNOX2-AS1–LUAD

Open the LUAD breakdown →