PKN3

Across TCGA patient cohorts, PKN3 protein abundance is significantly associated with the RNA expression of many other genes, with 2,185 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PKN3-associated genes across cancer lineages are PRDX2P1, RPL23AP48, and UBE2CP3. Each is linked with PKN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKN3-to-partner and partner-to-PKN3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PKN3 versus PRDX2P1 in OV, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKN3→partner) and Y-score (partner→PKN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PRDX2P1 →	+1.061	+0.635	.002	.002	3	2
BRCA	RPL23AP48 →	+0.959	+0.985	<.001	<.001	3	2
OV	UBE2CP3 →	+0.897	+0.721	.002	.002	3	2
OV	AK6P1 →	+0.293	+0.572	.007	.005	3	2
LSCC	DPM2 →	+0.526	+0.344	.001	.007	3	2
BRCA	RPL29P12 →	+1.526	+0.662	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,185 associations by consensus.

PKN3 vs PRDX2P1 — OV

Explore this scatter interactively →