PKN3

Across TCGA patient cohorts, PKN3 mutation is significantly associated with the RNA expression of many other genes, with 294 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKN3-associated genes across cancer lineages are NMNAT1P4, RN7SKP85, and RPL7AP61. Each is linked with PKN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKN3-to-partner and partner-to-PKN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NMNAT1P4 grouped by PKN3-low versus PKN3-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKN3→partner) and Y-score (partner→PKN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NMNAT1P4 →	+0.045	+4.578	.001	.008	3	2
LIHC	RN7SKP85 →	+0.144	+6.149	<.001	.002	3	2
STAD	RPL7AP61 →	+0.127	+3.691	<.001	.008	3	2
COAD	MTCO1P35 →	+0.317	+4.824	<.001	.002	3	2
BLCA	FAM243A →	+0.032	+5.311	<.001	.001	3	2
LUSC	RNU6-467P →	+0.203	+4.321	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 294 associations by consensus.

NMNAT1P4 by PKN3 expression — HNSC

Explore this box plot interactively →