PKN3

Across TCGA cell cohorts, PKN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,374 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PKN3-associated GO terms across cancer lineages are DNA integrity checkpoint signaling, Protein localization to chromosome, and Positive regulation of mitotic cell cycle phase transition. Each is linked with PKN3 in more than 13 cancer types. Because this analysis shows association rather than direction, both PKN3-to-partner and partner-to-PKN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA integrity checkpoint signaling grouped by PKN3-low versus PKN3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PKN3→partner) and Y-score (partner→PKN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA integrity checkpoint signaling →	+0.101	+1.675	.008	.001	3	14
SOFT_TISSUE	Protein localization to chromosome →	+0.087	+1.313	<.001	.006	3	14
PANCREAS	Positive regulation of mitotic cell cycle phase transition →	+0.114	+1.191	<.001	<.001	3	14
BONE	DNA damage checkpoint signaling →	+0.096	+1.663	.006	.001	3	13
LARGE_INTESTINE	Regulation of DNA-templated DNA replication →	+0.095	+1.468	<.001	<.001	3	13
BONE	Nucleoside monophosphate biosynthetic process →	+0.131	+1.771	.003	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,374 associations by consensus.

DNA integrity checkpoint signaling by PKN3 expression — BONE

Explore this box plot interactively →