PKN3

Across TCGA cell cohorts, PKN3 mutation is significantly associated with the RNA expression of many other genes, with 463 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PKN3-associated genes across cancer lineages are TXNDC15, PPP2R5E, and PBK. Each is linked with PKN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKN3-to-partner and partner-to-PKN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNDC15 grouped by PKN3-low versus PKN3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKN3→partner) and Y-score (partner→PKN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TXNDC15 →	+0.685	+3.502	<.001	.001	3	2
LARGE_INTESTINE	PPP2R5E →	+0.573	+3.169	<.001	.009	3	2
LARGE_INTESTINE	PBK →	+0.813	+3.386	.006	.001	3	2
LARGE_INTESTINE	ME2 →	+1.155	+3.502	<.001	.001	3	2
BLOOD_Leukemia	CFHR2 →	+0.135	+3.539	<.001	.002	3	2
OESOPHAGUS	DUXA →	+0.021	+4.392	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 463 associations by consensus.

TXNDC15 by PKN3 expression — LARGE_INTESTINE

Explore this box plot interactively →