PKN3

Across TCGA cell cohorts, PKN3 mutation is significantly associated with the mutation status of many other genes, with 6,359 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PKN3-associated genes across cancer lineages are TDRD12, PRRC2B, and MUC5AC. Each is linked with PKN3 in more than 5 cancer types. Because this analysis shows association rather than direction, both PKN3-to-partner and partner-to-PKN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TDRD12 grouped by PKN3-low versus PKN3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKN3→partner) and Y-score (partner→PKN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TDRD12 →	+4.930	+3.977	.001	.001	1	6
BLOOD_Leukemia	PRRC2B →	+3.498	+5.824	<.001	<.001	1	5
OVARY	MUC5AC →	+4.930	+3.977	.001	.001	1	5
OVARY	DEPDC5 →	+3.930	+3.632	.003	.003	1	5
CNS	COL7A1 →	+3.877	+5.139	.001	.001	1	5
OVARY	PLXNA1 →	+2.345	+3.196	.007	.007	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,359 associations by consensus.

TDRD12 by PKN3 expression — OVARY

Explore this box plot interactively →