PKN1

Across TCGA patient cohorts, PKN1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,423 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PKN1-associated genes across cancer lineages are SLA2, TLR8, and ARHGAP9. Each is linked with PKN1 in more than 7 cancer types. Because this analysis shows association rather than direction, both PKN1-to-partner and partner-to-PKN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PKN1 versus SLA2 in LSCC, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKN1→partner) and Y-score (partner→PKN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLA2 →	+0.792	+0.267	<.001	<.001	3	8
HNSC	TLR8 →	+1.191	+0.517	<.001	<.001	3	8
LSCC	ARHGAP9 →	+0.845	+0.331	<.001	<.001	3	8
LSCC	NCKAP1L →	+0.856	+0.322	<.001	<.001	3	8
LSCC	LILRB2 →	+0.757	+0.258	<.001	<.001	3	8
LSCC	WAS →	+0.814	+0.348	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,423 associations by consensus.

PKN1 vs SLA2 — LSCC

Explore this scatter interactively →