PKN1

Across TCGA pan-cancer cohorts, PKN1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PKN1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PKN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PKN1 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where PKN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PKN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.006	<.001	12	view →
KIRP	Female	II,III,IV	+1.307	<.001	11	view →
COAD	All	III,IV	+1.140	<.001	11	view →
LIHC	Female	II,III,IV	+1.772	<.001	8	view →
HNSC	All	II,III,IV	+0.710	.008	7	view →
BRCA	All	All	+0.425	<.001	6	view →
THCA	All	All	+0.218	<.001	6	view →
STAD	Male	II,III,IV	+1.180	.002	5	view →
CHOL	Female	All	+3.853	<.001	3	view →
LUSC	Male	All	−0.728	<.001	3	view →
LUAD	Female	All	−0.452	<.001	3	view →
BLCA	Male	IV	−1.304	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PKN1–KIRC

Open the KIRC breakdown →