PKN1

Across TCGA patient cohorts, PKN1 mutation is significantly associated with the RNA expression of many other genes, with 4,158 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKN1-associated genes across cancer lineages are CEP85, ACKR3, and DPEP1. Each is linked with PKN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PKN1-to-partner and partner-to-PKN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEP85 grouped by PKN1-low versus PKN1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKN1→partner) and Y-score (partner→PKN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CEP85 →	+0.468	+3.223	<.001	.008	3	3
UCEC	ACKR3 →	-0.744	-2.978	<.001	<.001	3	3
COAD	DPEP1 →	-2.047	-2.308	<.001	.006	3	3
UCEC	PITHD1 →	+0.372	+3.280	<.001	<.001	3	3
UCEC	TXLNA →	+0.310	+1.999	<.001	<.001	3	3
UCEC	PSMC3IP →	+0.708	+2.283	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,158 associations by consensus.

CEP85 by PKN1 expression — COAD

Explore this box plot interactively →