PKN1

Across TCGA patient cohorts, PKN1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKN1-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and Ku80. Each is linked with PKN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKN1-to-partner and partner-to-PKN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PKN1-low versus PKN1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKN1→partner) and Y-score (partner→PKN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EGFR_pY1068 →	-0.309	-2.691	.020	.006	3	2
UCEC	FoxM1 →	+0.179	+1.652	.035	.006	3	2
UCEC	Ku80 →	+0.224	+1.405	.003	.012	3	2
UCEC	PDK1 →	+0.091	+2.235	.010	.005	3	2
UCEC	Rad50 →	-0.179	-2.446	.025	.018	3	2
UCEC	ATM →	-0.433	-2.401	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

EGFR_pY1068 by PKN1 expression — COAD

Explore this box plot interactively →