PKN1

Across TCGA cell cohorts, PKN1 mutation is significantly associated with the RNA expression of many other genes, with 636 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PKN1-associated genes across cancer lineages are SLC25A51, CEP57L1, and GHRHR. Each is linked with PKN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PKN1-to-partner and partner-to-PKN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A51 grouped by PKN1-low versus PKN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKN1→partner) and Y-score (partner→PKN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC25A51 →	+0.497	+3.169	.002	.006	3	3
LARGE_INTESTINE	CEP57L1 →	+0.559	+3.252	.001	.002	3	3
BLOOD_Leukemia	GHRHR →	+0.230	+3.121	<.001	.003	3	2
BREAST	OR10T2 →	+0.110	+4.196	<.001	.006	3	2
LARGE_INTESTINE	ANKRD54 →	+0.515	+3.036	<.001	<.001	3	2
LARGE_INTESTINE	CBY1 →	+0.785	+3.860	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 636 associations by consensus.

SLC25A51 by PKN1 expression — LARGE_INTESTINE

Explore this box plot interactively →