PKN1

Across TCGA cell cohorts, PKN1 mutation is significantly associated with the mutation status of many other genes, with 6,502 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PKN1-associated genes across cancer lineages are CC2D1A, HNF1A, and OR2T4. Each is linked with PKN1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PKN1-to-partner and partner-to-PKN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CC2D1A grouped by PKN1-low versus PKN1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKN1→partner) and Y-score (partner→PKN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CC2D1A →	+4.614	+4.614	.006	.006	1	6
UPPER_AERODIGESTIVE_TRACT	HNF1A →	+5.392	+5.392	.004	.004	1	5
CNS	OR2T4 →	+4.614	+4.614	.006	.006	1	5
LUNG_NSCLC_LUAD	MYO1A →	+4.339	+4.339	.009	.009	1	5
UPPER_AERODIGESTIVE_TRACT	ARVCF →	+5.392	+5.392	.004	.004	1	5
BLOOD_Leukemia	FBN3 →	+1.929	+2.529	.001	.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,502 associations by consensus.

CC2D1A by PKN1 expression — CNS

Explore this box plot interactively →