PKMYT1

Across TCGA pan-cancer cohorts, PKMYT1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PKMYT1 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PKMYT1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PKMYT1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, LUAD, and CCRCC are the cancer types where PKMYT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.914	0.581	.037	4	view →
LUAD	DFS	Median	II,III,IV	0.214	0.866	.019	4	view →
CCRCC	OS	Quartile	All	1.000	0.780	.017	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PKMYT1–UCEC (DFS)

Open the UCEC breakdown →