PKMYT1

Across TCGA pan-cancer cohorts, PKMYT1 RNA differs between tumor and matched normal tissue in 18 of 18 cancer types tested, making tumor–normal expression one of PKMYT1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PKMYT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PKMYT1 is over-expressed in tumor.

COAD, HNSC, and LUAD are the cancer types where PKMYT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PKMYT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+2.582	<.001	12	view →
HNSC	Male	All	+2.356	<.001	12	view →
LUAD	Male	III,IV	+2.660	<.001	11	view →
KIRP	Male	III,IV	+2.338	<.001	11	view →
BLCA	Male	All	+2.292	<.001	11	view →
THCA	Male	III,IV	+0.977	<.001	11	view →
KIRC	Male	IV	+0.974	<.001	11	view →
STAD	Female	All	+2.967	<.001	9	view →
LIHC	Female	II,III,IV	+1.640	<.001	9	view →
UCEC	All	III,IV	+3.590	<.001	8	view →
LUSC	Male	III,IV	+3.537	<.001	8	view →
BRCA	All	II,III,IV	+2.455	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 18 lineages.

PKMYT1–COAD

Open the COAD breakdown →