PKMYT1

Across TCGA patient cohorts, PKMYT1 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKMYT1-associated genes across cancer lineages are p62 Lck ligand, 4E-BP1, and MEK1. Each is linked with PKMYT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKMYT1-to-partner and partner-to-PKMYT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by PKMYT1-low versus PKMYT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKMYT1→partner) and Y-score (partner→PKMYT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.717	+3.009	<.001	.019	3	2
UCEC	4E-BP1 →	+0.380	+2.837	.010	.035	3	1
UCEC	MEK1 →	+0.561	+3.169	.005	.020	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

p62 Lck ligand by PKMYT1 expression — UCEC

Explore this box plot interactively →