PKMYT1

Across TCGA cell cohorts, PKMYT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,668 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PKMYT1-associated GO terms across cancer lineages are Mitotic DNA replication, DNA replication initiation, and Cell cycle DNA replication initiation. Each is linked with PKMYT1 in more than 18 cancer types. Because this analysis shows association rather than direction, both PKMYT1-to-partner and partner-to-PKMYT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic DNA replication grouped by PKMYT1-low versus PKMYT1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PKMYT1→partner) and Y-score (partner→PKMYT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Mitotic DNA replication →	+0.196	+1.329	<.001	.002	3	19
BONE	DNA replication initiation →	+0.196	+1.581	.002	.003	3	18
PANCREAS	Cell cycle DNA replication initiation →	+0.221	+1.117	<.001	<.001	3	18
PANCREAS	Nuclear cell cycle DNA replication initiation →	+0.221	+1.117	<.001	<.001	3	18
PANCREAS	Mitotic DNA replication initiation →	+0.221	+1.117	<.001	<.001	3	18
OESOPHAGUS	Nuclear DNA replication →	+0.170	+1.663	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,668 associations by consensus.

Mitotic DNA replication by PKMYT1 expression — BONE

Explore this box plot interactively →