PKMP2

Across TCGA patient cohorts, PKMP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,508 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKMP2-associated GO terms across cancer lineages are Maturation of SSU-rRNA, Obsolete cellular response to extracellular stimulus, and Ribosome assembly. Each is linked with PKMP2 in more than 15 cancer types. Because this analysis shows association rather than direction, both PKMP2-to-partner and partner-to-PKMP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of SSU-rRNA grouped by PKMP2-low versus PKMP2-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PKMP2→partner) and Y-score (partner→PKMP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Maturation of SSU-rRNA →	+0.046	+0.096	<.001	<.001	3	16
STAD	Obsolete cellular response to extracellular stimulus →	+0.035	+0.067	<.001	<.001	3	15
STAD	Ribosome assembly →	+0.048	+0.094	<.001	<.001	3	15
STAD	Regulation of ubiquitin-dependent protein catabolic process →	+0.039	+0.062	<.001	<.001	3	15
STAD	Positive regulation of ubiquitin-dependent protein catabolic process →	+0.038	+0.074	<.001	<.001	3	15
STAD	Vesicle localization →	+0.038	+0.081	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,508 associations by consensus.

Maturation of SSU-rRNA by PKMP2 expression — STAD

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