PKMP2

Across TCGA pan-cancer cohorts, PKMP2 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PKMP2 data layer.

The strongest signal is observed in thymoma (THYM), where higher PKMP2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PKMP2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and KIRP show a favorable association.

THYM, LUAD, and PAAD are the cancer types where PKMP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	DFS	Tertile	III,IV	0.400	1.000	.001	51	view →
LUAD	OS	Median	II,III,IV	0.642	0.768	.001	51	view →
PAAD	DFS	Quartile	All	0.300	0.540	<.001	41	view →
STAD	OS	Quartile	All	0.398	0.838	.002	40	view →
BRCA	DFS	Tertile	All	0.570	1.000	.033	36	view →
KIRC	OS	Median	All	0.728	0.556	.001	25	view →
KIRP	OS	Quartile	III,IV	0.701	0.343	.036	20	view →
LUSC	DFS	Median	III,IV	0.144	0.821	<.001	18	view →
HNSC	DFS	Tertile	II,III,IV	0.305	0.423	.004	15	view →
SARC	OS	Tertile	All	0.322	0.675	.006	10	view →
SKCM	DFS	Median	IV	0.187	0.763	.006	9	view →
GBM	OS	Quartile	All	0.342	0.540	.004	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PKMP2–THYM (DFS)

Open the THYM breakdown →