PKLR

Across TCGA pan-cancer cohorts, PKLR mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PKLR data layer compared with 21 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PKLR mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PKLR expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

UCEC, CCRCC, and LSCC are the cancer types where PKLR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.423	1.000	.010	40	view →
CCRCC	DFS	Median	All	1.000	0.530	.001	27	view →
LSCC	DFS	Quartile	II,III,IV	0.647	0.945	.010	13	view →
GBM	OS	Median	All	0.599	0.448	.010	6	view →
LUAD	DFS	Quartile	III,IV	0.325	0.993	.006	6	view →
PDAC	OS	Median	IV	0.836	0.491	.024	3	view →
HNSC	DFS	Median	III,IV	1.000	0.937	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PKLR–UCEC (OS)

Open the UCEC breakdown →