PKLR

Across TCGA patient cohorts, PKLR RNA expression is significantly associated with the protein abundance of many other proteins, with 7,182 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible PKLR-associated proteins across cancer lineages are PALM3_S375, SEC24A, and PRKD2. Each is linked with PKLR in more than 2 cancer types. Because this analysis shows association rather than direction, both PKLR-to-partner and partner-to-PKLR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PKLR versus PALM3_S375 in COAD, with a Pearson correlation of 0.53.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PKLR→partner) and Y-score (partner→PKLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PALM3_S375 →	+0.942	+0.699	<.001	<.001	3	3
LSCC	SEC24A →	-0.305	-0.130	.001	.003	3	3
COAD	PRKD2 →	-0.213	-0.863	<.001	<.001	3	3
LSCC	RAB27A →	-0.531	-0.109	<.001	.001	3	3
CCRCC	CIT →	+0.477	+0.970	<.001	.001	3	3
COAD	FCER1G →	-0.522	-0.712	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,182 associations by consensus.

PKLR vs PALM3_S375 — COAD

Explore this scatter interactively →