PKLR

Across TCGA patient cohorts, PKLR protein abundance is significantly associated with the RNA expression of many other genes, with 4,713 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible PKLR-associated genes across cancer lineages are HBA2, HBB, and FOSB. Each is linked with PKLR in more than 6 cancer types. Because this analysis shows association rather than direction, both PKLR-to-partner and partner-to-PKLR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PKLR versus HBA2 in GBM, with a Pearson correlation of 0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKLR→partner) and Y-score (partner→PKLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HBA2 →	+1.973	+0.871	<.001	<.001	3	7
BRCA	HBB →	+1.932	+0.713	<.001	<.001	3	7
OV	FOSB →	+2.130	+0.637	<.001	<.001	3	6
GBM	HBA1 →	+1.844	+0.843	<.001	<.001	3	6
GBM	ALAS2 →	+0.740	+0.624	<.001	<.001	3	5
GBM	PPBP →	+1.191	+0.725	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,713 associations by consensus.

PKLR vs HBA2 — GBM

Explore this scatter interactively →