PKLR

Across TCGA patient cohorts, PKLR mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKLR-associated genes across cancer lineages are GAPDH, HER3_pY1289, and eEF2. Each is linked with PKLR in more than 2 cancer types. Because this analysis shows association rather than direction, both PKLR-to-partner and partner-to-PKLR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by PKLR-low versus PKLR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKLR→partner) and Y-score (partner→PKLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.609	+3.000	.001	<.001	3	3
UCEC	HER3_pY1289 →	+0.078	+2.019	.013	.017	3	3
UCEC	eEF2 →	+0.354	+3.459	.007	.005	3	2
UCEC	MSH6 →	-0.302	-2.459	.012	.018	3	2
UCEC	NF2 →	+0.204	+1.847	.010	.008	3	2
UCEC	PCNA →	+0.171	+1.874	.031	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

GAPDH by PKLR expression — UCEC

Explore this box plot interactively →