PKLR

Across TCGA cell cohorts, PKLR RNA expression is significantly associated with the go_rna of many other GO terms, with 2,277 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PKLR-associated GO terms across cancer lineages are Embryonic skeletal joint development, Vesicle tethering, and Protein polyglycylation. Each is linked with PKLR in more than 4 cancer types. Because this analysis shows association rather than direction, both PKLR-to-partner and partner-to-PKLR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Embryonic skeletal joint development grouped by PKLR-low versus PKLR-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PKLR→partner) and Y-score (partner→PKLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Embryonic skeletal joint development →	+0.133	+0.157	<.001	.004	3	5
UPPER_AERODIGESTIVE_TRACT	Vesicle tethering →	+0.088	+0.026	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	Protein polyglycylation →	+1.062	+0.019	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	Excitatory postsynaptic potential →	-0.160	-0.028	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	Protein localization to lysosome →	+0.064	+0.017	.001	.006	3	5
BREAST	Regulation of myoblast fusion →	+0.084	+0.054	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,277 associations by consensus.

Embryonic skeletal joint development by PKLR expression — LARGE_INTESTINE

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