PKLR

Across TCGA cell cohorts, PKLR mutation is significantly associated with the RNA expression of many other genes, with 260 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PKLR-associated genes across cancer lineages are PEX13, DESI2, and RWDD2A. Each is linked with PKLR in more than 1 cancer types. Because this analysis shows association rather than direction, both PKLR-to-partner and partner-to-PKLR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEX13 grouped by PKLR-low versus PKLR-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKLR→partner) and Y-score (partner→PKLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PEX13 →	+0.517	+3.115	.001	.009	3	2
LARGE_INTESTINE	DESI2 →	+0.492	+3.169	.002	.009	3	2
LARGE_INTESTINE	RWDD2A →	+0.538	+3.588	<.001	<.001	3	2
LARGE_INTESTINE	THAP9 →	+0.548	+3.087	.001	.006	3	2
LARGE_INTESTINE	SCAI →	+0.506	+2.451	.007	.009	3	2
LARGE_INTESTINE	PARD6G →	+0.906	+3.502	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 260 associations by consensus.

PEX13 by PKLR expression — BLOOD_Leukemia

Explore this box plot interactively →