PKIG

Across TCGA patient cohorts, PKIG mutation is significantly associated with the RNA expression of many other genes, with 1,721 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKIG-associated genes across cancer lineages are TRDD1, PRYP2, and VDAC3P1. Each is linked with PKIG in more than 1 cancer types. Because this analysis shows association rather than direction, both PKIG-to-partner and partner-to-PKIG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRDD1 grouped by PKIG-low versus PKIG-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKIG→partner) and Y-score (partner→PKIG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRDD1 →	+1.452	+9.057	<.001	.003	3	1
BRCA	PRYP2 →	+0.074	+7.731	<.001	.009	3	1
UCEC	VDAC3P1 →	+0.345	+3.233	.002	.009	3	1
UCEC	MIR98 →	+0.354	+2.801	<.001	.005	3	1
UCEC	RNU6-6P →	+0.644	+2.227	<.001	.008	3	1
UCEC	CYFIP1 →	+0.709	+3.491	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,721 associations by consensus.

TRDD1 by PKIG expression — BRCA

Explore this box plot interactively →