PKIG

Across TCGA pan-cancer cohorts, PKIG RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of PKIG’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PKIG RNA is repressed in tumor relative to normal tissue. In most cancer types PKIG is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

BLCA, KICH, and LUSC are the cancer types where PKIG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PKIG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−2.941	<.001	11	view →
KICH	Female	All	−2.169	<.001	11	view →
LUSC	All	III,IV	−2.074	<.001	9	view →
LUAD	Female	III,IV	−2.025	<.001	8	view →
COAD	Male	All	−0.842	<.001	7	view →
UCEC	All	III,IV	−1.761	<.001	6	view →
THCA	Male	IV	−0.743	.001	6	view →
BRCA	Female	II,III,IV	−0.439	<.001	4	view →
LIHC	All	All	+0.408	<.001	4	view →
CHOL	All	All	+1.191	<.001	3	view →
READ	All	All	−1.045	.013	2	view →
PRAD	All	All	−0.738	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

PKIG–BLCA

Open the BLCA breakdown →