PKIG

Across TCGA patient cohorts, PKIG mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKIG-associated genes across cancer lineages are CMP, Sebocytes, and Th2 cells. Each is linked with PKIG in more than 1 cancer types. Because this analysis shows association rather than direction, both PKIG-to-partner and partner-to-PKIG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CMP grouped by PKIG-low versus PKIG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKIG→partner) and Y-score (partner→PKIG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CMP →	+0.037	+2.332	.016	.020	2	2
UCEC	Sebocytes →	-0.032	-2.300	.011	.036	3	1
UCEC	Th2 cells →	+0.268	+2.329	.003	.020	3	1
UCEC	Endothelial cells →	-0.045	-3.416	.019	.005	1	1
UCEC	lymphatic Endothelial cells →	-0.027	-3.405	.024	.005	1	1
UCEC	mv Endothelial cells →	-0.033	-3.448	.006	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CMP by PKIG expression — UCEC

Explore this box plot interactively →