PKIB

Across TCGA patient cohorts, PKIB protein abundance is significantly associated with the RNA expression of many other genes, with 9,131 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PKIB-associated genes across cancer lineages are INPP4B, USP6NL, and C12orf45. Each is linked with PKIB in more than 3 cancer types. Because this analysis shows association rather than direction, both PKIB-to-partner and partner-to-PKIB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PKIB versus INPP4B in BRCA, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKIB→partner) and Y-score (partner→PKIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	INPP4B →	+1.192	+0.792	<.001	.001	3	3
OV	USP6NL →	-0.670	-1.000	.002	<.001	3	3
LUAD	C12orf45 →	-0.323	-0.618	.003	.003	3	3
BRCA	ZG16B →	+1.521	+0.934	<.001	<.001	3	3
BRCA	UBXN10 →	+1.424	+0.752	<.001	<.001	3	3
BRCA	RAET1E →	+0.434	+0.665	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,131 associations by consensus.

PKIB vs INPP4B — BRCA

Explore this scatter interactively →