PKIB

Across TCGA pan-cancer cohorts, PKIB RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PKIB data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PKIB RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PKIB expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

LUAD, HNSC, and BRCA are the cancer types where PKIB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.758	0.858	<.001	98	view →
HNSC	DFS	Median	IV	0.678	0.470	<.001	69	view →
BRCA	DFS	Median	III,IV	0.928	0.828	.002	57	view →
MESO	OS	Tertile	All	0.264	0.469	.002	54	view →
LGG	DFS	Median	All	0.329	0.478	<.001	47	view →
READ	OS	Tertile	All	0.898	0.618	.010	47	view →
LIHC	OS	Tertile	All	0.360	0.576	<.001	34	view →
LAML	DFS	Median	All	0.468	0.675	.002	34	view →
KIRC	DFS	Quartile	All	0.771	0.563	.004	28	view →
UCEC	DFS	Tertile	All	0.561	0.739	.012	18	view →
ESCA	OS	Median	All	0.659	1.000	.020	18	view →
UCS	OS	Tertile	IV	0.239	0.783	.024	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PKIB–LUAD (OS)

Open the LUAD breakdown →