PKIB

Across TCGA patient cohorts, PKIB mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKIB-associated genes across cancer lineages are MIR3122, RNU6-694P, and MIR610. Each is linked with PKIB in more than 1 cancer types. Because this analysis shows association rather than direction, both PKIB-to-partner and partner-to-PKIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3122 grouped by PKIB-low versus PKIB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKIB→partner) and Y-score (partner→PKIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR3122 →	+1.274	+4.302	<.001	.008	3	1
LUSC	RNU6-694P →	+0.323	+6.578	<.001	.001	3	1
LUSC	MIR610 →	+0.402	+4.984	<.001	.009	3	1
LUSC	OR8B1P →	+0.078	+5.882	<.001	.002	3	1
LUSC	TUBB3P2 →	+0.505	+5.211	<.001	.007	3	1
LUSC	TUBB4BP6 →	+0.241	+6.191	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

MIR3122 by PKIB expression — UCEC

Explore this box plot interactively →