PKIB

Across TCGA cell cohorts, PKIB RNA expression is significantly associated with the go_rna of many other GO terms, with 2,855 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PKIB-associated GO terms across cancer lineages are Multivesicular body organization, Multivesicular body assembly, and Negative regulation of NK T cell activation. Each is linked with PKIB in more than 7 cancer types. Because this analysis shows association rather than direction, both PKIB-to-partner and partner-to-PKIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Multivesicular body organization grouped by PKIB-low versus PKIB-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PKIB→partner) and Y-score (partner→PKIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Multivesicular body organization →	+0.070	+2.426	.009	.001	3	8
OESOPHAGUS	Multivesicular body assembly →	+0.074	+2.420	.004	.001	3	7
BLOOD_Lymphoma	Negative regulation of NK T cell activation →	+0.479	+1.208	.008	.004	3	7
BREAST	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway →	-0.047	-1.701	.001	.009	2	8
LUNG_NSCLC_LUAD	Chondroblast differentiation →	-1.050	-1.455	.001	.005	3	6
OVARY	Secondary alcohol biosynthetic process →	+0.155	+1.316	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,855 associations by consensus.

Multivesicular body organization by PKIB expression — OESOPHAGUS

Explore this box plot interactively →