PKIA

Across TCGA patient cohorts, PKIA mutation is significantly associated with the RNA expression of many other genes, with 1,148 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKIA-associated genes across cancer lineages are SC4MOP, RPA2P2, and MIR4757. Each is linked with PKIA in more than 1 cancer types. Because this analysis shows association rather than direction, both PKIA-to-partner and partner-to-PKIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SC4MOP grouped by PKIA-low versus PKIA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKIA→partner) and Y-score (partner→PKIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SC4MOP →	+0.044	+3.646	.004	<.001	3	2
UCEC	RPA2P2 →	+0.332	+1.999	<.001	.008	3	2
SKCM	MIR4757 →	+0.357	+5.199	<.001	.003	3	2
UCEC	TAF9 →	+0.619	+2.606	<.001	.005	3	1
UCEC	MIR6772 →	-0.945	-4.087	<.001	<.001	3	1
UCEC	TUBGCP5 →	+0.438	+2.748	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,148 associations by consensus.

SC4MOP by PKIA expression — UCEC

Explore this box plot interactively →