PKIA

Across TCGA pan-cancer cohorts, PKIA RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PKIA data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PKIA RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PKIA expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCS show a favorable association.

UVM, SKCM, and UCS are the cancer types where PKIA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.583	0.881	<.001	124	view →
SKCM	DFS	Tertile	All	0.690	0.550	.002	75	view →
UCS	OS	Tertile	II,III,IV	0.795	0.393	.003	48	view →
BRCA	DFS	Tertile	III,IV	0.534	0.299	.001	42	view →
LGG	DFS	Median	All	0.476	0.330	<.001	37	view →
UCEC	DFS	Tertile	All	0.533	0.768	<.001	32	view →
BLCA	DFS	Quartile	II,III,IV	0.430	0.293	.008	31	view →
KIRC	DFS	Tertile	IV	0.439	0.668	.012	29	view →
LIHC	OS	Median	III,IV	0.432	0.754	.001	23	view →
COAD	OS	Tertile	II,III,IV	0.835	0.715	.019	12	view →
STAD	OS	Median	All	0.631	0.740	.007	9	view →
THCA	DFS	Tertile	All	0.994	0.924	.011	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PKIA–UVM (DFS)

Open the UVM breakdown →