PKIA

Across TCGA patient cohorts, PKIA mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKIA-associated genes across cancer lineages are A-Raf_pS299, JNK2, and Ku80. Each is linked with PKIA in more than 1 cancer types. Because this analysis shows association rather than direction, both PKIA-to-partner and partner-to-PKIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by PKIA-low versus PKIA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKIA→partner) and Y-score (partner→PKIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.153	-2.807	.003	.003	3	1
UCEC	JNK2 →	+0.230	+2.115	.008	.019	3	1
UCEC	Ku80 →	+0.271	+2.820	.008	.001	3	1
UCEC	p62 Lck ligand →	+0.437	+2.469	.002	.010	3	1
UCEC	PDCD4 →	-0.439	-2.115	.033	.019	3	1
UCEC	Rictor_pT1135 →	-0.104	-2.459	.020	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

A-Raf_pS299 by PKIA expression — UCEC

Explore this box plot interactively →