PKIA

Across TCGA cell cohorts, PKIA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,756 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PKIA-associated GO terms across cancer lineages are Regulation of chromosome organization, Positive regulation of chromosome condensation, and Regulation of mitotic metaphase/anaphase transition. Each is linked with PKIA in more than 10 cancer types. Because this analysis shows association rather than direction, both PKIA-to-partner and partner-to-PKIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromosome organization grouped by PKIA-low versus PKIA-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PKIA→partner) and Y-score (partner→PKIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of chromosome organization →	+0.059	+1.638	<.001	<.001	3	11
BLOOD_Leukemia	Positive regulation of chromosome condensation →	+0.129	+1.658	<.001	<.001	3	9
BLOOD_Leukemia	Regulation of mitotic metaphase/anaphase transition →	+0.083	+1.538	<.001	<.001	3	9
SOFT_TISSUE	Kinetochore assembly →	+0.098	+1.413	<.001	.002	3	9
BLOOD_Leukemia	Mitotic nuclear division →	+0.068	+1.931	<.001	<.001	3	8
SKIN	Organic acid transport →	-0.052	-1.277	.001	.006	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,756 associations by consensus.

Regulation of chromosome organization by PKIA expression — SOFT_TISSUE

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