PKIA-AS1

Across TCGA pan-cancer cohorts, PKIA-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PKIA-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PKIA-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PKIA-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

KIRC, UCS, and UCEC are the cancer types where PKIA-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	III,IV	0.253	0.511	<.001	111	view →
UCS	OS	Tertile	II,III,IV	0.691	0.153	<.001	96	view →
UCEC	OS	Median	All	0.594	0.744	<.001	74	view →
KIRP	DFS	Quartile	All	0.777	0.935	.004	43	view →
UVM	OS	Tertile	III,IV	0.253	0.828	<.001	42	view →
LUAD	OS	Tertile	All	0.238	0.521	.001	28	view →
STAD	DFS	Tertile	All	0.404	0.589	.011	27	view →
LIHC	DFS	Median	All	0.356	0.485	.005	27	view →
SKCM	OS	Tertile	III,IV	0.530	0.272	.002	22	view →
HNSC	OS	Median	All	0.603	0.774	.003	22	view →
BLCA	DFS	Tertile	II,III,IV	0.572	0.467	.019	21	view →
READ	DFS	Tertile	III,IV	0.567	0.815	.015	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PKIA-AS1–KIRC (DFS)

Open the KIRC breakdown →