PKIA-AS1

Across TCGA pan-cancer cohorts, PKIA-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PKIA-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PKIA-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PKIA-AS1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KICH, KIRC, and LUSC are the cancer types where PKIA-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PKIA-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	+0.577	<.001	9	view →
KIRC	All	All	−0.038	<.001	6	view →
LUSC	All	All	+0.201	<.001	5	view →
BLCA	All	All	+0.248	.023	4	view →
THCA	Female	All	−0.113	<.001	4	view →
PAAD	Male	All	+0.120	.016	2	view →
PRAD	All	All	+0.089	.048	2	view →
LUAD	All	All	+0.134	.031	1	view →
LIHC	All	All	+0.057	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PKIA-AS1–KICH

Open the KICH breakdown →