Across TCGA patient cohorts, PKHD1L1 mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKHD1L1-associated genes across cancer lineages are TFRC, Ku80, and eEF2. Each is linked with PKHD1L1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PKHD1L1-to-partner and partner-to-PKHD1L1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKHD1L1→partner) and Y-score (partner→PKHD1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	TFRC →	+0.483	+2.222	.010	.010	3	5
UCEC	Ku80 →	+0.130	+0.980	.017	.004	3	5
LUSC	eEF2 →	+0.113	+1.272	.008	.001	3	4
LUSC	GAPDH →	+0.481	+1.485	.002	.048	3	4
UCEC	Cyclin-B1 →	+0.446	+1.700	<.001	.001	3	4
HNSC	Notch1 →	+0.201	+1.874	.016	.045	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Exploration

PKHD1L1 survival (RNA) · tumor vs normal (RNA) · all PKHD1L1 data types