Across TCGA pan-cancer cohorts, PKHD1L1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PKHD1L1 data layer compared with 11 for mutation status and 2 for mass-spec protein.
The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PKHD1L1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PKHD1L1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.
SKCM, KIRP, and HNSC are the cancer types where PKHD1L1 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.