Across TCGA cell cohorts, PKHD1L1 mutation is significantly associated with the RNA expression of many other genes, with 1,331 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PKHD1L1-associated genes across cancer lineages are GAS2L1, SDHB, and MMACHC. Each is linked with PKHD1L1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PKHD1L1-to-partner and partner-to-PKHD1L1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKHD1L1→partner) and Y-score (partner→PKHD1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GAS2L1 →	+0.892	+1.765	<.001	<.001	3	4
LARGE_INTESTINE	SDHB →	+0.499	+2.129	<.001	<.001	3	3
LARGE_INTESTINE	MMACHC →	+0.565	+1.706	.003	<.001	3	3
LUNG_SCLC	TRPM2 →	+1.625	+2.115	.004	.005	3	3
LUNG_SCLC	MARCKS →	-1.005	-2.459	.004	.003	3	3
OVARY	TBX22 →	+0.098	+2.599	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,331 associations by consensus.

Exploration

PKHD1L1 survival (RNA) · tumor vs normal (RNA) · all PKHD1L1 data types