PKHD1

Across TCGA patient cohorts, PKHD1 protein abundance is significantly associated with the RNA expression of many other genes, with 92 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible PKHD1-associated genes across cancer lineages are DDX58, NKX3-2, and PIGZ. Each is linked with PKHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKHD1-to-partner and partner-to-PKHD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PKHD1 versus DDX58 in CCRCC, with a Pearson correlation of 0.81.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKHD1→partner) and Y-score (partner→PKHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DDX58 →	+0.975	+0.918	.001	.002	3	1
CCRCC	NKX3-2 →	-0.205	-1.107	.003	.006	3	1
CCRCC	PIGZ →	+0.688	+0.918	.002	.002	3	1
CCRCC	BECN1 →	+0.259	+0.918	.007	.002	3	1
CCRCC	NCOA2 →	+0.833	+0.918	.004	.002	3	1
CCRCC	CNTNAP5 →	+3.509	+1.035	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

PKHD1 vs DDX58 — CCRCC

Explore this scatter interactively →