PKHD1

Across TCGA pan-cancer cohorts, PKHD1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PKHD1 data layer compared with 10 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PKHD1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PKHD1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

KIRC, COAD, and SCLC are the cancer types where PKHD1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.741	0.522	<.001	150	view →
COAD	OS	Median	II,III,IV	0.798	0.899	.001	76	view →
SCLC	DFS	Quartile	II,III,IV	0.685	0.186	.005	51	view →
UCS	DFS	Median	II,III,IV	0.562	0.160	<.001	50	view →
MESO	DFS	Median	II,III,IV	0.450	0.302	.013	37	view →
THYM	DFS	Tertile	All	0.807	0.967	.001	29	view →
PAAD	OS	Quartile	All	0.289	0.641	.005	22	view →
LIHC	DFS	Median	All	0.421	0.212	.001	20	view →
KIRP	DFS	Quartile	All	1.000	0.766	.014	19	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	18	view →
UVM	OS	Tertile	All	0.349	0.695	.025	14	view →
BRCA	DFS	Quartile	All	0.972	0.931	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PKHD1–KIRC (OS)

Open the KIRC breakdown →