PKHD1

Across TCGA patient cohorts, PKHD1 mutation is significantly associated with the RNA expression of many other genes, with 9,255 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKHD1-associated genes across cancer lineages are OIP5, MELK, and PSMC3IP. Each is linked with PKHD1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PKHD1-to-partner and partner-to-PKHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OIP5 grouped by PKHD1-low versus PKHD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKHD1→partner) and Y-score (partner→PKHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OIP5 →	+0.652	+1.394	<.001	<.001	3	7
UCEC	MELK →	+0.623	+1.207	<.001	<.001	3	7
UCEC	PSMC3IP →	+0.492	+1.207	<.001	<.001	3	7
LUAD	EME1 →	+0.643	+2.544	<.001	<.001	3	6
UCEC	RBBP8 →	+0.574	+1.111	<.001	<.001	3	6
LUAD	ACOX2 →	-0.570	-1.585	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,255 associations by consensus.

OIP5 by PKHD1 expression — UCEC

Explore this box plot interactively →