PKHD1

Across TCGA patient cohorts, PKHD1 mutation is significantly associated with the total protein of many other genes, with 107 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKHD1-associated genes across cancer lineages are PCNA, CD49b, and 4E-BP1. Each is linked with PKHD1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PKHD1-to-partner and partner-to-PKHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PKHD1-low versus PKHD1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKHD1→partner) and Y-score (partner→PKHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.205	+1.523	.007	.009	3	7
LUSC	CD49b →	+0.272	+1.777	<.001	.001	3	5
LUAD	4E-BP1 →	+0.383	+3.919	<.001	<.001	2	6
UCEC	Cyclin-B1 →	+0.552	+1.616	<.001	<.001	3	5
STAD	TFRC →	+0.515	+3.169	.013	.017	3	5
COAD	eIF4E →	+0.171	+2.012	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 107 associations by consensus.

PCNA by PKHD1 expression — COAD

Explore this box plot interactively →