PKHD1

Across TCGA cell cohorts, PKHD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,160 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PKHD1-associated GO terms across cancer lineages are Regulation of kidney size, Adenylate cyclase-activating serotonin receptor signaling pathway, and Regulation of NMDA receptor activity. Each is linked with PKHD1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PKHD1-to-partner and partner-to-PKHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of kidney size grouped by PKHD1-low versus PKHD1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PKHD1→partner) and Y-score (partner→PKHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of kidney size →	+1.617	+1.413	.002	.001	3	6
BONE	Adenylate cyclase-activating serotonin receptor signaling pathway →	+0.143	+0.515	<.001	.001	3	6
BREAST	Regulation of NMDA receptor activity →	+1.089	+0.298	.001	.003	3	6
LUNG_NSCLC_LUAD	Startle response →	-0.067	-0.428	.004	.005	3	6
PANCREAS	Vesicle budding from membrane →	+0.046	+0.281	.004	.004	2	6
SOFT_TISSUE	Regulation of mRNA catabolic process →	+0.084	+0.118	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,160 associations by consensus.

Regulation of kidney size by PKHD1 expression — LIVER

Explore this box plot interactively →