PKHD1

Across TCGA cell cohorts, PKHD1 mutation is significantly associated with the RNA expression of many other genes, with 1,224 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PKHD1-associated genes across cancer lineages are RFC2, BORCS5, and MAPK12. Each is linked with PKHD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PKHD1-to-partner and partner-to-PKHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFC2 grouped by PKHD1-low versus PKHD1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKHD1→partner) and Y-score (partner→PKHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RFC2 →	+0.562	+2.444	<.001	<.001	3	4
LARGE_INTESTINE	BORCS5 →	+0.568	+2.130	<.001	<.001	3	4
LARGE_INTESTINE	MAPK12 →	+1.216	+2.064	.001	.004	3	3
OVARY	RANGAP1 →	+0.586	+3.078	.003	.007	3	3
OVARY	TBR1 →	+0.052	+2.819	.004	.002	3	3
OVARY	ORC5 →	+0.782	+3.093	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,224 associations by consensus.

RFC2 by PKHD1 expression — BLOOD_Leukemia

Explore this box plot interactively →