PKDREJ

Across TCGA patient cohorts, PKDREJ mutation is significantly associated with the RNA expression of many other genes, with 5,236 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKDREJ-associated genes across cancer lineages are DCK, DEPDC1, and ISOC1. Each is linked with PKDREJ in more than 3 cancer types. Because this analysis shows association rather than direction, both PKDREJ-to-partner and partner-to-PKDREJ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCK grouped by PKDREJ-low versus PKDREJ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKDREJ→partner) and Y-score (partner→PKDREJ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DCK →	+0.562	+1.595	<.001	<.001	3	4
UCEC	DEPDC1 →	+0.504	+1.332	<.001	<.001	3	4
UCEC	ISOC1 →	+0.386	+1.401	.003	.001	3	4
UCEC	TIPIN →	+0.512	+2.053	<.001	<.001	3	4
UCEC	MCAT →	+0.324	+2.627	<.001	<.001	3	4
UCEC	CCM2L →	-0.352	-2.230	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,236 associations by consensus.

DCK by PKDREJ expression — UCEC

Explore this box plot interactively →