PKDREJ

Across TCGA patient cohorts, PKDREJ mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKDREJ-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-E2, and STAT3_pY705. Each is linked with PKDREJ in more than 3 cancer types. Because this analysis shows association rather than direction, both PKDREJ-to-partner and partner-to-PKDREJ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PKDREJ-low versus PKDREJ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKDREJ→partner) and Y-score (partner→PKDREJ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.565	+1.874	<.001	.001	3	4
BRCA	Cyclin-E2 →	+0.315	+2.814	.008	.037	3	3
UCEC	STAT3_pY705 →	-0.335	-1.836	<.001	<.001	3	3
UCEC	AR →	-0.248	-1.047	.013	.018	3	3
UCEC	TFRC →	+0.482	+2.392	<.001	<.001	3	3
UCEC	ATM →	-0.613	-2.247	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Caspase-7-cleavedD198 by PKDREJ expression — UCEC

Explore this box plot interactively →