PKDREJ

Across TCGA cell cohorts, PKDREJ mutation is significantly associated with the RNA expression of many other genes, with 218 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PKDREJ-associated genes across cancer lineages are GOLGA6L6, TAS2R41, and OR4M2. Each is linked with PKDREJ in more than 1 cancer types. Because this analysis shows association rather than direction, both PKDREJ-to-partner and partner-to-PKDREJ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOLGA6L6 grouped by PKDREJ-low versus PKDREJ-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKDREJ→partner) and Y-score (partner→PKDREJ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GOLGA6L6 →	+0.009	+4.369	<.001	.008	3	2
LUNG_NSCLC_LUAD	TAS2R41 →	+0.041	+3.481	<.001	.004	3	2
LUNG_NSCLC_LUAD	OR4M2 →	+0.138	+3.887	<.001	.002	3	2
LARGE_INTESTINE	AVP →	+0.028	+2.494	<.001	<.001	3	2
LARGE_INTESTINE	MAD2L1 →	+0.593	+2.386	.002	.007	3	2
BLOOD_Lymphoma	CHRNA9 →	+0.301	+3.506	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 218 associations by consensus.

GOLGA6L6 by PKDREJ expression — SOFT_TISSUE

Explore this box plot interactively →