PKDCC

Across TCGA patient cohorts, PKDCC mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKDCC-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and INPP4B. Each is linked with PKDCC in more than 1 cancer types. Because this analysis shows association rather than direction, both PKDCC-to-partner and partner-to-PKDCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PKDCC-low versus PKDCC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKDCC→partner) and Y-score (partner→PKDCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.283	-3.459	.024	.005	3	1
UCEC	FoxM1 →	+0.274	+3.459	.035	.005	3	1
UCEC	INPP4B →	-0.418	-3.321	.010	.010	3	1
UCEC	Ku80 →	+0.354	+3.472	.002	.002	3	1
UCEC	MEK1 →	+0.498	+3.169	.006	.019	3	1
UCEC	p62 Lck ligand →	+0.518	+3.469	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

EGFR_pY1068 by PKDCC expression — UCEC

Explore this box plot interactively →